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Are E-Cigarettes Safe? Here’s What the Science Says

In 1965, when Herbert Gilbert was granted the first patent on a smoke- and tobacco-­free cigarette, he wrote that the product would “provide a safe and harmless means for and method of smoking.”

More than 60 years later, however, modern iterations of Gilbert’s invention have sparked debate in the public-health community. E-cigarettes, which have grown increasingly popular in the past five years, were designed as a tool to help people quit ­smoking—and by doing so they should drastically reduce rates of lung cancer and other diseases. But the question is, does that potential outweigh their possible risks to human health?

Traditional cigarettes work by simple combustion: when tobacco is lit, it combines with oxygen and creates an inhalable smoke. E-cigarettes, sold by brands including Juul, Blu and Vuse, heat a chemical-­packed liquid that typically contains nicotine and often a flavoring agent, creating an aerosol. By delivering ­nicotine without tar and other nasty by-­products of combustion, e-cigarettes purportedly give smokers a healthier alternative to cigarettes while still satisfying cravings.

It seems like a win-win. But in practice, there is no consensus yet about whether or not e-cigarettes effectively help smokers ditch cigarettes. Vapes, as they’re called, contain fewer of the cancer-­causing chemicals found in traditional cigarettes (like arsenic, benzene and formaldehyde), but there is little long-term data about their effects on health—and preliminary science suggests that they may harm the lungs and heart. Plus, while e-cigs are made for and legally available only to adults, they’re popular among ­teenagers—­potentially priming a new generation for nicotine addiction and tobacco use, experts worry.

While public-health officials in some places, like the U.K., are strongly in favor of e-cigarettes, the World Health Organization is more wary. In the U.S., Dr. Scott ­Gottlieb—­commissioner of the Food and Drug Administration (FDA), which regulates the ­devices—says he believes e-cigarettes are good for public health, despite the unknowns. E-cigs are “not risk-free,” Gottlieb says, but the possibilities they hold for adult smokers trying to quit, like reduced rates of lung cancer and better overall respiratory health, are important.

“If we were able to switch every adult smoker completely onto an e-cigarette product, we would have a significant impact on overall public health,” Gottlieb says. Tony Abboud, executive director of the e-cig trade group Vapor Technology Association, agrees, calling e-cigarettes “among the most promising public-­health innovations of the 21st century.”

But some researchers studying their effects aren’t convinced. They believe there’s not enough evidence showing that e-cigarettes help adults quit smoking to outweigh a growing number of studies that suggest they come with health harms, including a higher risk of heart disease and increased rates of respiratory conditions. “What are the effects of [e-cigarettes] when a user takes 200 puffs a day for 20 years?” asks Thomas Eissenberg, director of the Center for the Study of Tobacco Products at Virginia Commonwealth University. “Anyone who says they know the answer to that question needs to present some data.”

The long-term effects of e-cigarette use aren’t the only unknowns. It’s also unclear whether vapes actually help smokers quit in the first place.

Mixed results

Some studies (supported by plenty of anecdotal evidence from users) have found that e-cigarettes can make smoking cessation easier. But others have found the opposite: that they make smokers more likely to continue using cigarettes, potentially because they sustain a nicotine habit. E-cigarettes are not FDA approved as smoking-­cessation devices, and vaping companies cannot make health claims about their products without this approval; manufacturers usually call them cigarette alternatives for adult smokers.

Juul is the most popular e-cigarette. According to recent data from the Centers for Disease Control and Prevention (CDC), Juul sold 16.2 million of its sleek, flash-drive-­resembling devices in 2017, 641% more than the year before. The company says it’s conducting studies on smoking cessation, toxicology and more. “We want to understand everything and we want to share all that data, because that’s ultimately what’s going to move the needle for the public-health conversation,” says Ashley Gould, Juul’s chief administrative officer. Gould also emphasizes that Juul was founded “to provide a satisfying alternative to cigarettes, with the objective of completely eliminating cigarettes.”

But many smokers who turn to e-cigarettes are not making the switch completely. Research from the CDC found that in 2015, about 59% of adults who used e-cigarettes also smoked. (­Adolescents who vape are also more likely than their peers to smoke cigarettes as well, according to a recent RAND Corporation study.) While some experts believe that replacing any amount of cigarette smoking with vaping is a good thing, some research suggests that dual use may be riskier than either smoking or vaping alone. An August studypublished in the American Journal of Preventive Medicine found that both daily smoking and vaping are associated with a higher risk of heart attack, and that doing the two concurrently compounds those risks.

E-cigarettes may also have a large impact on lung cancer. Compared with cigarettes, they contain far fewer of the ingredients known to cause cancer, and the ones they do contain are present at lower levels. There is also no evidence proving that e-cigarettes cause cancer. Given that cigarette smoking is the number-one risk factor for lung cancer, the assumption is that if smokers switched from cigarettes to vapes, lung-­cancer rates would potentially plummet.

But scientists still don’t know how long-term use of e-cigarettes affects health—in part because the devices just haven’t been around long enough for the necessary rigorous research to have been done.

Plus, comparisons with cigarettes go only so far, since e-cigarettes are a radically different product, says Silvia Balbo, assistant professor of environmental health sciences at the University of Minnesota School of Public Health. “When you’re looking at chemicals that are present both in tobacco regular cigarettes and e-cigarettes, you can do a comparison,” she says. “But if you consider the mixture on its own and how all the different compounds and chemicals are interacting, then that poses a different question.”